Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
نویسندگان
چکیده
منابع مشابه
Determinant Spreading of T Helper Cell 2 (Th2) Responses to Pancreatic Islet Autoantigens
The nature (Th1 versus Th2) and dynamics of the autoimmune response during the development of insulin-dependent diabetes mellitus (IDDM) and after immunotherapy are unclear. Here, we show in nonobese diabetic (NOD) mice that the autoreactive T cell response starts and spreads as a pure Th1 type autoimmunity, suggesting that a spontaneous Th1 cascade underlies disease progression. Surprisingly, ...
متن کاملHLA-DQ-regulated T-cell responses to islet cell autoantigens insulin and GAD65.
HLA-DQ is strongly associated with genetic predisposition to type 1 diabetes. It is assumed that HLA-DQ molecules exert their effects on the disease via the presentation of peptides from islet autoantigens to CD4(+) T-cells, but little information regarding HLA-DQ-restricted, islet antigen-specific, autoreactive T-cells is available. To investigate the role of HLA-DQ in the immune response to i...
متن کاملEvidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens.
In type 1 diabetes, insulin-producing beta cells in the islets of the pancreas are destroyed by autoreactive T cells. Rotavirus (RV) has been implicated in the pathogenesis of type 1 diabetes. Peptides in VP7, a major immunogenic protein of RV, have high sequence similarity to T cell epitope peptides in the islet autoantigens tyrosine phosphatase-like insulinoma Ag 2 (IA2) and glutamic acid dec...
متن کاملExposure to exogenous insulin promotes IgG1 and the T-helper 2-associated IgG4 responses to insulin but not to other islet autoantigens.
Insulin immunization in animal models induces T-helper (Th) 2-like antibody subclass responses to insulin and other beta-cell antigens. The aim of this study was to determine whether exposure to insulin in humans resulted in a similar subclass bias of the humoral immune response. Levels of IgG subclass antibodies to insulin (IAs), GAD, and IA-2 were measured before and after treatment with insu...
متن کاملCross-reactive Immune Responses between Enteroviruses and Islet Cell Autoantigens Härkönen, Taina, Cross-reactive Immune Responses between Enteroviruses and Islet Cell Autoantigens
Previous scientific data suggests that enterovirus infections, especially those caused by coxsackieviruses have a role in the pathogenesis of type 1 diabetes. One mechanism by which viral infection could initiate or accelerate diabetogenic process in humans is ‘molecular mimicry’, induction of antiviral immune responses which cross-react with self-epitopes in insulin producing β-cells. This stu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1997
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.186.12.2039